Good manufacturing practice production of human stem cells for somatic cell and gene therapy
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چکیده
منابع مشابه
Good manufacturing practice-compliant expansion of marrow-derived stem and progenitor cells for cell therapy.
Ex vivo expansion is being used to increase the number of stem and progenitor cells for autologous cell therapy. Initiation of pivotal clinical trials testing the efficacy of these cells for tissue repair has been hampered by the challenge of assuring safe and high-quality cell production. A strategy is described here for clinical-scale expansion of bone marrow (BM)-derived stem cells within a ...
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Successful isolation, derivation and culturing of human pluripotent stem cells, including human embryonic stem cells (hESCs) and human induced pluripotent stem (hiPSCs) cells in laboratory scale has opened new horizones for cell therapy applications such as tissue engineering and regenerative medicine. However, most of the cell therapy protocols using these unique cells require large number of ...
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s:3115:"Background: During reproductive life, the human endometrium undergoes around 500 cycles of growth, breakdown and regeneration. This outstanding regenerative capability is the basis for cyclic endometrial preparation and its dysfunction is involved in pathological disorders. Endometrial regeneration is mediated by the existence of a specialized endometrial stem cell (SC) population recen...
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Stem cells are cells with the ability to divide for indefinite periods and to give rise to specialized cells. Stem cell therapy has now been emerged as an extraordinary promise to treat a wide range of diseases and conditions. However, except blood stem cell transfer by bone marrow transplant which has been used as an standard practice for more than 50 years, nearly all of therapeutic potenti...
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Adipose-derived stem cells (ADSCs) are excellent for regenerative medicine. Like mesenchymal stem cells, ADSCs possess multi-potent differentiation capacity that enables them to differentiate into osteoblasts, chondrocytes and adipocytes, as well as trans-differentiation into other cells. ADSC transplantation has gained attention in recent years, especially in vitro expanded ADSC transplantatio...
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ژورنال
عنوان ژورنال: Stem Cells
سال: 1997
ISSN: 1066-5099,1549-4918
DOI: 10.1002/stem.5530150835